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IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart.
Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann T, Belousov VV, Katschinski DM. Nanadikar MS, et al. Among authors: vergel leon am. Nat Commun. 2023 Apr 14;14(1):2123. doi: 10.1038/s41467-023-37744-x. Nat Commun. 2023. PMID: 37055412 Free PMC article.
Metabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth syndrome.
Chowdhury A, Boshnakovska A, Aich A, Methi A, Vergel Leon AM, Silbern I, Lüchtenborg C, Cyganek L, Prochazka J, Sedlacek R, Lindovsky J, Wachs D, Nichtova Z, Zudova D, Koubkova G, Fischer A, Urlaub H, Brügger B, Katschinski DM, Dudek J, Rehling P. Chowdhury A, et al. EMBO Mol Med. 2023 Sep 11;15(9):e17399. doi: 10.15252/emmm.202317399. Epub 2023 Aug 3. EMBO Mol Med. 2023. PMID: 37533404 Free PMC article.
O2 affects mitochondrial functionality ex vivo.
Nanadikar MS, Vergel Leon AM, Borowik S, Hillemann A, Zieseniss A, Belousov VV, Bogeski I, Rehling P, Dudek J, Katschinski DM. Nanadikar MS, et al. Among authors: vergel leon am. Redox Biol. 2019 Apr;22:101152. doi: 10.1016/j.redox.2019.101152. Epub 2019 Feb 23. Redox Biol. 2019. PMID: 30825773 Free PMC article.